Key Scope：
1.Performing structure based design and antigen/antibody docking to select key residues for point mutation or library construction, finally optimize antibody drug candidates from multiple angles
2.Antibody humanization/affinity maturation/developability optimization/bispecific design/other protein modality design/etc
3.Work with team to validate the in silico designs by molecular cloning
4.Summarize and present data timely to project & management team for decision making.

主要工作職責(zé)：
1.基于蛋白質(zhì)結(jié)構(gòu)分析和預(yù)測，抗原抗體對接等手段，設(shè)計(jì)點(diǎn)突變或者文庫，從多個(gè)維度優(yōu)化抗體藥物的特性，篩選有治療潛力的分子
2.抗體人源化，親和力成熟，穩(wěn)定性優(yōu)化，雙特異抗體的設(shè)計(jì)等
3.完成分子克隆的構(gòu)建，和團(tuán)隊(duì)一起驗(yàn)證蛋白質(zhì)優(yōu)化的設(shè)計(jì)
4.及時(shí)分析匯報(bào)數(shù)據(jù)，幫助項(xiàng)目組做決定


Key Delivery：
1.As a member of ATD (Antibody Therapeutic Discovery), work with team to discover & optimize antibody drug and deliver clinical candidates
2.Finish drug design and corresponding molecular cloning independently
3.Timely deliver results

主要交付結(jié)果
1.作為ATD-治療性抗體發(fā)現(xiàn)團(tuán)隊(duì)的一員，完成抗體藥物的優(yōu)化設(shè)計(jì)并最終交付臨床候選分子
2.獨(dú)立完成蛋白藥物的設(shè)計(jì)和相應(yīng)的克隆工作
3.按時(shí)交付結(jié)果


Education & Working Experience Preference:
1.PhD/postdoc in biochemistry, protein design, or relevant fields;